Depression is a growing concern worldwide, yet its impact on political trust remains underexplored. Using a nationally representative panel survey from China, we find a robust negative association between depressive symptoms and political trust. This effect is amplified by perceptions of inequality, as individuals who see society as unfair are more likely to blame the government for their hardship. The effect is pronounced among potentially volatile groups like unemployed young males, whose tendency to externalize stress can translate distrust into social unrest. Crucially, the effect is also significant among groups traditionally considered better off such as public sector employees, who face intense pressures of ideological conformity in the workplace. This widespread “silent suffering” highlights a critical psychological pathway through which poor mental health, an increasingly pressing issue, can intensify social discontent and weaken regime stability.