Previous research finds that misinformation is often difficult to correct once a person accepts it as truth. Nonetheless, a few studies have shown evidence that fact-checkers can help lower an individual’s susceptibility to believing false news and rumors. Our study builds on this research by examining the fact-checking inoculation effect on political misinformation (also known as “fake news”) that circulated on the Internet in the months following the election of President Donald Trump. Using an experimental design, we find only selected instances of inoculation effects. Instead, our results are consistent with previous studies that show individuals are more likely to accept or reject misinformation based on whether it is consistent with their pre-existing partisan and ideological beliefs. However, partisanship and ideology played a much stronger role in predicting believability for fake news stories critical of Democrats than stories critical of Republicans.