Disinformation is currently an important threat to modern democratic societies and has a critical impact on the quality of public life. This article presents an organic approach to understanding of the issue of disinformation that is derived from the context of the Czech Republic. The approach builds on the various similarities with virology where disinformation is compared to a hostile virus that is spread in a certain environment and may penetrate the human body. Contribution is providing Czech experience in eight areas related to creation and spread of disinformation and analyzing obstacles for building disinformation resilience.