Several steps will be necessary to combat COVID-19 misinformation and disinformation campaigns. Private sector specialists in risk communications, advertising, linguistics, and social cognition could collaborate in devising accurate public health information crafted to overcome psychological resistance. Governments could enact regulations that discourage microtargeting of social media advertisements. Government agencies that regulate medical advertising also might expand their oversight to COVID-19 medical claims. Perhaps most important, government leaders must respect factual information.